True non-denatured Whey Protein Concentrate like Pulse is the optimal nature-prescribed precursor (required for the production) of Glutathione (GSH). It contains exceptionally high amounts of non-denatured Cysteine and Glutamine, the amino acids required for intracellular GSH production. It naturally contains the full range of proteins that enhance immune function including the protein bound fats that, in whey protein isolates, have been removed.
There are many whey proteins to choose from. The critical factors to ask yourself when choosing a whey supplement are:
1. How was the whey produced? Is it low temperature processed?
2. Is it a by-product (of cheese making) or a primary product?
3. What are the actual amounts of the important proteins measured by independent lab analysis?
4. Is it made from 100% grass fed cows?
5. Is it free of chemical artificial sweeteners and GMO’s?
Below, you can read about some specific diseases that are linked to low glutathione levels in the body and how a bioactive whey supplement can help.
Benefits of Glutathione for Athletes
Strong muscular activity generates oxyradicals, leading to muscle fatigue and poorer performance. Glutathione neutralizes these radicals. Whey proteins promote muscular development (Sports Medicine 21; 213 – 238, 1996). Recent research indicates that propensities toward many degenerative diseases and aging itself are related to the capacity of the cell to robustly recover from oxidative insult. The capacity of a cell to recover from such insult can be determined by measuring the intracellular stores of Glutathione. (Noelle et al., 1981)
Antioxidants are well documented to play vital roles in health maintenance and disease prevention. Glutathione is our cell’s own major antioxidant. Why not use what is natural? (Biochemical Pharmacology 47:2113-2123 1994)
Benefits of Glutathione for Disease
Immune depressed individuals have lower Glutathione (GSH) levels when fighting disease. Lymphocytes, cells vital for your immune response, depend on GSH for their proper function and replication (Immunology 61: 503-508 1987). Cellular depletion of Glutathione has been implicated as a causative or contributory factor in many pathologies including Parkinson’s, Alzheimer’s, cataracts, arteriosclerosis, cystic fibrosis, malnutrition, aging, AIDS and cancer (Bounous et al., 1991). In addition, Glutathione is essential in supporting the immune system, including natural killer cells (Droege et al., 1997) and in the maintenance of T-lymphocytes (Gutman, 1998).
Glutathione plays a role in eliminating many carcinogens as well as maintaining immune function towards providing stronger anti-tumor defenses. (Cancer Letters 57: 91-94 1991)
It is known that as we age, there is a precipitous drop in Glutathione levels. Lower Glutathione levels are implicated in many diseases associated with aging, including Cataracts, Alzheimer’s disease, Parkinson’s, Arteriosclerosis and others. Journal of Clinical Epidemiology 47: 1021-28 1994
Low Glutathione levels have been demonstrated in neurodegenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig’s Disease), Alzheimer’s, and Parkinson’s, among others. The Lancel 344: 796-798 1994
Toxins, Pollution, Radiation
Glutathione detoxifies many pollutants, carcinogens, and poisons, including many in fuel exhaust and cigarette smoke. It retards damage from radiation such as seen with loss of the ozone (Annual Review of Biochemistry 52 : 711-780 1983). The liver is the main detoxification organ of the body. In the liver we find very high concentrations of GSH, as it is a major factor in numerous biochemical detoxification pathways. Numerous studies have demonstrated that patients with compromised liver function due to alcohol abuse have significant reductions of GSH in the liver (Lamestro, 1995).
Low Glutathione levels with result in poor survival in AIDS patients. Much literature has been written demonstrating the role of enhancing GSH levels in AIDS patients (Proc. National Acad. Science USA 94: 2967-72 1997).
Below is more information on the benefits for HIV and AIDS.
Role of Cysteine and Glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
The combination of abnormally low plasma cysteine and glutamine levels, low natural killer (NK) cell activity, skeletal muscle wasting or muscle fatigue, and increased rates of urea production defines a complex of abnormalities that is tentatively called “low CG syndrome.” These symptoms are found in patients with HIV infection, cancer, major injuries, sepsis, Crohn’s disease, ulcerative colitis, chronic fatigue syndrome, and to some extent in over trained athletes. The coincidence of these symptoms in diseases of different etiological origin suggests a causal relationship. The low NK cell activity in most cases is not life threatening, but may be disastrous in HIV infection because it may compromise the initially stable balance between the immune system and virus, and trigger disease progression.
This hypothesis is supported by the coincidence observed between the decrease of CD4+ T cells and a decrease in the plasma cysteine level. In addition, recent studies revealed important clues about the role of cysteine and Glutathione in the development of skeletal muscle wasting. Evidence suggests that:
1) The cysteine level is regulated primarily by the normal post absorptive skeletal muscle protein catabolism.
2) The cysteine level itself is a physiological regulator of nitrogen balance and body cell mass.
3) The cysteine-mediated regulatory circuit is compromised in various catabolic conditions, including old age
4) Cysteine supplementation may be a useful therapy if combined with disease-specific treatments such as antiviral therapy in HIV infection
1. Biochemical Pharmacology 47:2113-2123 1994
2. Droege W, Holm E. Role of cysteine and glutathione HIV-wasting and other diseases associated with muscle wasting and immunoglobulin function. FASEB J 1997; 11:10771089
3. Whey Protein Report, Current Concepts on Whey Protein Usage, Prepared for The Cleveland Eye Clinic, by: David Marshall, Jr., O.D., Ph.D., Consult.